The Synaptic Organization of the Brain

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The neural basis of brain function requires an interdisciplinary approach at various levels, and recent studies on synaptic organization are driving significant advancements in this understanding. This fifth edition incorporates findings from the mouse and human genome projects, providing insights for molecular biologists focused on the functional genomics and proteomics of the brain. Key questions addressed include the cell and circuit functions of gene products, alongside an introduction to supporting neuroscience databases. New techniques featured include 2-photon confocal laser microscopy of dendrites and spines, biochemical analyses, and dual patch and multielectrode recordings, all complemented by behavioral and gene-targeting methods. Leading experts synthesize molecular, anatomical, functional, and behavioral data into cohesive accounts for well-studied brain regions. Each chapter follows a consistent format, detailing neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, and membrane and dendritic properties, concluding with how circuits influence specific behaviors. This structured approach highlights common principles across regions while addressing unique adaptations, serving as a model for understanding the neural basis of behavior.