Current Topics in Microbiology and Immunology - 85: Immunology of the Nicotinic Acetylcholine Receptor

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184 strony
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General aspects of nucleic acid uptake by mammalian cells have been the subject of several reviews during the last few years (PAGANO, 1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967). These reviews covered methods used for the infection of cells by viral nucleic acids as well as interaction of mammalian cells with non-viral nucleic acids. This article is restricted to a discussion of experiments with poliovirus RNA and focuses special attention on the steps following the uptake of RNA into a cell, aspects that were not discussed in earlier review articles. The fate of input RNA once inside the cell is determined by the host cell but experimental conditions can be chosen to favor the survival of input RNA and the induction of a virus growth cycle by interfering with host-cell meta bolism through events that, in the case of infection with intact virus, might be controlled by viral proteins.

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Current Topics in Microbiology and Immunology - 85: Immunology of the Nicotinic Acetylcholine Receptor, G. Schmidt, H. J. Humphrey James Welch, H. G. Schweiger, Amory Lovins, Werner Arber, J. Klein, Monika S. K. Fuchs, A. Gerylovová, J. Oppenheim, D. M. Jones, F. Melchers, P. K. Vogt, O. Maaløe, Werner Henle, R. Rott, L. Syru?ek, Peter Hans Hofschneider, D. Maubon, M. Geffard, M. H. Teyssier, J. M. Schlaefer, A. C. Pereira, C. Stiffel, M. Szyfres, H. Maier, D. A. Sant'Anna, A. M. Hartmann, J. C. A. Fonseca, S. Falkow, S. Durum, P. Koldovský, H. Koprowski

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Rok wydania: 1979
Oprawa: (twarda)

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Tytuł: Current Topics in Microbiology and Immunology - 85: Immunology of the Nicotinic Acetylcholine Receptor
Język: angielski
Autorzy: G. Schmidt, H. J. Humphrey James Welch, H. G. Schweiger, Amory Lovins, Werner Arber, J. Klein, Monika S. K. Fuchs, A. Gerylovová, J. Oppenheim, D. M. Jones, F. Melchers, P. K. Vogt, O. Maaløe, Werner Henle, R. Rott, L. Syru?ek, Peter Hans Hofschneider, D. Maubon, M. Geffard, M. H. Teyssier, J. M. Schlaefer, A. C. Pereira, C. Stiffel, M. Szyfres, H. Maier, D. A. Sant'Anna, A. M. Hartmann, J. C. A. Fonseca, S. Falkow, S. Durum, P. Koldovský, H. Koprowski
Wydawca: Springer
Rok wydania: 1979
Oprawa: twarda
Liczba stron: 184
ISBN10: 3540094105
ISBN13: 9783540094104
Seria
Kategorie: Literatura naukowa Nauka & Matematyka Biologia
Literatura naukowa Nauka & Matematyka Ekologia
Tagi: Nauki przyrodnicze, Nauka, Tematyka medyczna, Tematy ekologiczne, Badania naukowe, Mikrobiologia, Immunologia, Badania medyczne
Opis: General aspects of nucleic acid uptake by mammalian cells have been the subject of several reviews during the last few years (PAGANO, 1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967). These reviews covered methods used for the infection of cells by viral nucleic acids as well as interaction of mammalian cells with non-viral nucleic acids. This article is restricted to a discussion of experiments with poliovirus RNA and focuses special attention on the steps following the uptake of RNA into a cell, aspects that were not discussed in earlier review articles. The fate of input RNA once inside the cell is determined by the host cell but experimental conditions can be chosen to favor the survival of input RNA and the induction of a virus growth cycle by interfering with host-cell meta bolism through events that, in the case of infection with intact virus, might be controlled by viral proteins.