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Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.
Zakup książki
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Język
- Rok wydania
- 2012
- Oprawa
- (twarda)
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- Tytuł
- Heteroaromatic Lipoxin A4 Analogues
- Podtytuł
- Synthesis and Biological Evaluation
- Język
- angielski
- Autorzy
- Colm Duffy
- Wydawca
- Springer Berlin Heidelberg
- Rok wydania
- 2012
- Oprawa
- twarda
- Liczba stron
- 152
- ISBN13
- 9783642246319
- Seria
- Springer Theses
- Kategorie
- Tagi
- Opis
- Focusing on the synthesis and evaluation of stable lipoxin analogues, the thesis presents groundbreaking work by Colm Duffy, who successfully created a pyridine-containing LXA4 analogue in enantiomerically pure form for the first time. The study reveals that both epimers suppress key cytokines linked to inflammatory diseases, with the (R)-epimer demonstrating superior efficacy. Additionally, Duffy developed a thiophene-containing analogue, showing promising biological activity, which has sparked further research into synthesizing more heteroaromatic analogues for evaluation.