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Mononuclear Phagocytes in the Central Nervous System

Origin, Mode of Distribution, and Function of Progressive Microglia, Perivascular Cells of ... Neurologie Neurology Series)

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  • 173 strony
  • 7 godzin czytania

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A number of years ago Prof. J. Peiffer (Tiibingen/FRG) asked whether cerebros- nal fluid cells originate in blood cells. With this question, the first seeds were sown for the research which resulted in this book. The original question was eventually ex­ panded to whether extravascular hematogenous cells are present in the nervous sys­ tem. In the course of my research this question became more and more concentrated on the demonstration of monocyte derivatives (i.e., mononuclear phagocytes) within the nervous system. While these questions are certainly not new, they regularly crop up when micro­ glia are to be classified, particularly progressive microglia. Three extensive surveys were published during the past few years, all of which arrived at different conclusions (Cammermeyer, 1970b; Vaughn and Skoff, 1972; Fujita and Kitamura, 1976). In ad­ dition to progressive microglia, other active phagocytes were observed which I refer to as "perivascular cells," "free subarachnoidal cells," and "epiplexus cells." These cells were seldom described in the literature, and then predominantly in another context. A pre­ sentation based on the hypothesis that the cell types of the central nervous system have po­ tentially identical kinetics and functional potency has not been published.

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Mononuclear Phagocytes in the Central Nervous System, Margaret M. Clarkson M. Oehmichen

Język
Rok wydania
1978
Oprawa
(twarda)
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Tytuł
Mononuclear Phagocytes in the Central Nervous System
Podtytuł
Origin, Mode of Distribution, and Function of Progressive Microglia, Perivascular Cells of ... Neurologie Neurology Series)
Język
angielski
Wydawca
Springer
Rok wydania
1978
Oprawa
twarda
Liczba stron
173
ISBN10
3540089586
ISBN13
9783540089582
Seria
Tagi
Opis
A number of years ago Prof. J. Peiffer (Tiibingen/FRG) asked whether cerebros- nal fluid cells originate in blood cells. With this question, the first seeds were sown for the research which resulted in this book. The original question was eventually ex­ panded to whether extravascular hematogenous cells are present in the nervous sys­ tem. In the course of my research this question became more and more concentrated on the demonstration of monocyte derivatives (i.e., mononuclear phagocytes) within the nervous system. While these questions are certainly not new, they regularly crop up when micro­ glia are to be classified, particularly progressive microglia. Three extensive surveys were published during the past few years, all of which arrived at different conclusions (Cammermeyer, 1970b; Vaughn and Skoff, 1972; Fujita and Kitamura, 1976). In ad­ dition to progressive microglia, other active phagocytes were observed which I refer to as "perivascular cells," "free subarachnoidal cells," and "epiplexus cells." These cells were seldom described in the literature, and then predominantly in another context. A pre­ sentation based on the hypothesis that the cell types of the central nervous system have po­ tentially identical kinetics and functional potency has not been published.